An estimated 10,000 Napoli supporters, including the team's most famous player Diego Maradona, are expected to make the trip to the Spanish capital for the first competitive meeting with Real Madrid since the 1987.
News of all that's transpired on and off the football field
Champions Barcelona lost 2-0 at Celta Vigo while Getafe earned an important 2-0 win over Girona in their bid to secure Champions League qualification.
Atletico Madrid maintained a two-point lead in La Liga with a 3-0 victory at Las Palmas and Barcelona and Real Madrid stayed hard on their heels with thumping wins over Athletic Bilbao and Sporting Gijon on Sunday.
Real Madrid were made to toil by the 10 men of Athletic Bilbao but eventually won 3-1 on Tuesday thanks to two strikes from Karim Benzema to go level on points with La Liga leaders Real Sociedad.
Dele Alli condemned Champions League holders Real Madrid to a horrendous Wembley debut with two goals as Tottenham Hotspur reached the last 16 with a stunning 3-1 victory.
Portugal international Goncalo Guedes fired Valencia into the lead in the 35th minute with a thumping shot from inside the area which was too powerful for Madrid goalkeeper Keylor Navas.
Villa's chief executive Christian Purslow said 10 first-team players are among 14 positive cases of coronavirus at the club.
Real Madrid beat Manchester United 2-1 on Tuesday to lift the European Super Cup for the fourth time as they became the first team to retain the trophy since AC Milan in 1990.
Here are five talking points from the weekend in La Liga:
Images from Saturday's La Liga action.
The Portuguese forward put his team on the verge of their third final in four years and took his tally to 103 goals in the competition as he helped Madrid vanquish their neighbours at the Santiago Bernabeu.
Arsenal named a strong side captained by Mesut Ozil while Real had Bale on the bench and Eden Hazard, wearing the number 50 shirt, starting alongside fellow new signing Luka Jovic in attack.
News of all that's transpired on and off the football field
The win increased Zinedine Zidane's side's advantage at the top of the standings to six points
Real Madrid's Sergio Ramos scored in the 90th minute to hold FC Barcelona to a 1-1 draw at the Camp Nou on Saturday.
Barcelona's last Champions League triumph came in 2015, and since then they have failed to get beyond the quarter-finals while Real Madrid have monopolised the trophy.
News of all that's transpired on and off the football field
Real Madrid defender Nacho was the unlikely hero as they snatched a 1-0 win at Real Valladolid on Sunday to capitalise on Barcelona's defeat at Valencia this weekend and move three points clear of their rivals at the top of La Liga. Serie A leaders Juventus suffered a shock 2-1 defeat at Napoli on Sunday, with coach Maurizio Sarri returning to his former club for the first time, though Cristiano Ronaldo still managed to score for an eighth league game in a row for the visitors.
Images from the football matches played across Europe on Wednesday.
Alvaro Morata again proved decisive from the bench by striking a late winner against Athletic Bilbao and firing a lacklustre Real Madrid to the top of La Liga on Sunday. The Spain international has been afforded limited opportunities in his first season back at Real following two years with Juventus, struggling to usurp first choice forwards Gareth Bale, Cristiano Ronaldo and Karim Benzema. Morata has made just four league starts, but has scored four times in all competitions.
The win took second-placed Real to 62 points after 29 games, two behind champions Barca who beat Leganes 2-0 on Tuesday.
Real were smarting from a surprise 1-1 draw at struggling Elche in their last match and were missing captain Sergio Ramos, who was out with a stomach bug.
Cristiano Ronaldo may have played his last game for Real Madrid after winning a fourth Champions League crown with the Spanish side in a 3-1 victory over Liverpool on Saturday, saying he would soon make an announcement on his future.
Facts and figures ahead of Saturday's Champions League final between holders Real Madrid and Liverpool in Kiev:
Here is a look at what happened in their previous Euro semis...
Aguero is expected to be the first of a number of arrivals at the Camp Nou this summer
Holders Real Madrid reached the Champions League final for a third year in a row after taking advantage of Bayern Munich's carelessness in attack and defence to draw 2-2 in their semi-final second leg on Tuesday, and winning 4-3 on aggregate, at the Santiago Bernabeu, in Madrid, Spain, on Tuesday.
Like an ailing heavyweight, Spain and their hopes of a third straight European title ended in a tame surrender as their 2-0 defeat by Italy represented the definitive end to a golden era in their footballing history. A first-half effort from defender Giorgio Chiellini and a stoppage-time goal by striker Graziano Pelle sent the Azzurri into the quarter-finals at Euro 2016 and left Spain to mull over a second successive failure on the international stage.
Holders Real Madrid came from a goal down to snatch a precious 2-1 victory at wasteful Bayern Munich on Wednesday and carry a considerable advantage into their Champions League semi-final second leg in Spain.
Barcelona coach Ronald Koeman has joined other managers in lashing out at the packed European football calendar after deciding to rest Lionel Messi for Tuesday's Champions League trip to Dynamo Kyiv.
Real Madrid are determined to create an intimidating atmosphere for visitors VfL Wolfsburg as they try to overturn a two-goal deficit in Tuesday's Champions League quarter-final second leg at the Santiago Bernabeu stadium.
'They aren't machines, they are the best players in their position but they aren't unbeatable or unsurpassable.'
Real Madrid forwards Marco Asensio and Karim Benzema struck to give their side a 2-0 win at home to Eibar in La Liga
Wolfsburg shock Real Madrid 2-0 to crown big European night.
The injury list in the La Liga keeps growing as the season progresses and this time Lionel Messi and Gareth Bale are the unfortunate victims...
Real Madrid and Atletico each slipped 10 points behind La Liga leaders Barcelona after an intense Madrid derby finished goalless and the Catalans picked up an 11th victory in 12 games by winning 3-0 at Leganes.
A superb strike from Jose Luis Morales condemned Real Madrid to a 1-0 defeat away to Levante on Saturday which saw them unseated at the top of the La Liga standings by Barcelona. Real's problems deepened with a suspected ankle injury to Eden Hazard, who limped off the pitch four days before their Champions League showdown with Manchester City and a week before their showdown with Barca in the 'Clasico'. Real's problems deepened with a suspected ankle injury to Eden Hazard, who limped off the pitch four days before their Champions League showdown with Manchester City and a week before their showdown with Barca in the 'Clasico'.
News of all that's transpired on and off the football field
A Marco Asensio-inspired Real Madrid crushed Eibar 3-0 to close the gap on La Liga leaders Barcelona to five points on Sunday, with Karim Benzema starting on the bench.
